201 research outputs found

    Stability analysis of genetic regulatory network with additive noises

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    <p>Abstract</p> <p>Background</p> <p>Genetic regulatory networks (GRN) can be described by differential equations with SUM logic which has been found in many natural systems. Identification of the network components and transcriptional rates are critical to the output behavior of the system. Though transcriptional rates cannot be measured in vivo, biologists have shown that they are alterable through artificial factors in vitro.</p> <p>Results</p> <p>This study presents the theoretical research work on a novel nonlinear control and stability analysis of genetic regulatory networks. The proposed control scheme can drive the genetic regulatory network to desired levels by adjusting transcriptional rates. Asymptotic stability proof is conducted with Lyapunov argument for both noise-free and additive noises cases. Computer simulation results show the effectiveness of the control design and robustness of the regulation scheme with additive noises.</p> <p>Conclusions</p> <p>With the knowledge of interaction between transcriptional factors and gene products, the research results can be applied in the design of model-based experiments to regulate gene expression profiles.</p

    The Effects of Shape-taste Congruence on Product Evaluations

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    The background design of a product presented online is important to attract consumers’ attention and further help them make proper judgments about the product. Although many studies have investigated factors of advertising background design, few focus on the effect of shape feature in the background on product evaluations. The present research investigates the influence of congruency between the shape in the background design and product taste perception on consumer product evaluations by using a pretest and three experiments. The results show that shape-taste congruency intensifies product evaluations with an increase evaluation of sweet-taste products and a decreases evaluation of sour-taste products (study1a & 1b). We explain the effect of shape-taste congruency through positive affect (study 2). In addition, an individual’s design sensitivity moderates the effect of shape-taste congruency on product evaluations, which means the effect of shape-taste congruency will disappear for people with low design sensitivity (study 3). The research provides important implications for online retailers in product display design

    Predicting Fire Season Severity in South America Using Sea Surface Temperature Anomalies

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    Fires in South America cause forest degradation and contribute to carbon emissions associated with land use change. Here we investigated the relationship between year-to-year changes in satellite-derived estimates of fire activity in South America and sea surface temperature (SST) anomalies. We found that the Oceanic Ni o Index (ONI) was correlated with interannual fire activity in the eastern Amazon whereas the Atlantic Multidecadal Oscillation (AMO) index was more closely linked with fires in the southern and southwestern Amazon. Combining these two climate indices, we developed an empirical model that predicted regional annual fire season severity (FSS) with 3-5 month lead times. Our approach provides the foundation for an early warning system for forecasting the vulnerability of Amazon forests to fires, thus enabling more effective management with benefits for mitigation of greenhouse gas and air pollutant emissions

    EVE: Environmental Adaptive Neural Network Models for Low-power Energy Harvesting System

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    IoT devices are increasingly being implemented with neural network models to enable smart applications. Energy harvesting (EH) technology that harvests energy from ambient environment is a promising alternative to batteries for powering those devices due to the low maintenance cost and wide availability of the energy sources. However, the power provided by the energy harvester is low and has an intrinsic drawback of instability since it varies with the ambient environment. This paper proposes EVE, an automated machine learning (autoML) co-exploration framework to search for desired multi-models with shared weights for energy harvesting IoT devices. Those shared models incur significantly reduced memory footprint with different levels of model sparsity, latency, and accuracy to adapt to the environmental changes. An efficient on-device implementation architecture is further developed to efficiently execute each model on device. A run-time model extraction algorithm is proposed that retrieves individual model with negligible overhead when a specific model mode is triggered. Experimental results show that the neural networks models generated by EVE is on average 2.5X times faster than the baseline models without pruning and shared weights

    Estimation of tomato water status with photochemical reflectance index and machine learning: Assessment from proximal sensors and UAV imagery

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    Tracking plant water status is a critical step towards the adaptive precision irrigation management of processing tomatoes, one of the most important specialty crops in California. The photochemical reflectance index (PRI) from proximal sensors and the high-resolution unmanned aerial vehicle (UAV) imagery provide an opportunity to monitor the crop water status efficiently. Based on data from an experimental tomato field with intensive aerial and plant-based measurements, we developed random forest machine learning regression models to estimate tomato stem water potential (ψstem), (using observations from proximal sensors and 12-band UAV imagery, respectively, along with weather data. The proximal sensor-based model estimation agreed well with the plant ψstem with R2 of 0.74 and mean absolute error (MAE) of 0.63 bars. The model included PRI, normalized difference vegetation index, vapor pressure deficit, and air temperature and tracked well with the seasonal dynamics of ψstem across different plots. A separate model, built with multiple vegetation indices (VIs) from UAV imagery and weather variables, had an R2 of 0.81 and MAE of 0.67 bars. The plant-level ψstem maps generated from UAV imagery closely represented the water status differences of plots under different irrigation treatments and also tracked well the temporal change among flights. PRI was found to be the most important VI in both the proximal sensor- and the UAV-based models, providing critical information on tomato plant water status. This study demonstrated that machine learning models can accurately estimate the water status by integrating PRI, other VIs, and weather data, and thus facilitate data-driven irrigation management for processing tomatoes

    Implementation of the Timetable Problem Using Self-assembly of DNA Tiles

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    DNA self-assembly is a promising paradigm for nanotechnology. Recently, many researches demonstrate that computation by self-assembly of DNA tiles may be scalable. In this paper, we show how the tile self-assembly process can be used for implementing the timetable problem. First the timetable problem can be converted into the graph edge coloring problem with some constraints, then we give the tile self-assembly model by constructing three small systems including nondeterministic assigning system, copy system and detection system to perform the graph edge coloring problem, thus the algorithm is proposed which can be successfully solved the timetable problem with the computation time complexity ofΘ(mn), parallely and at very low cost

    Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

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    SummaryDefective apoptosis renders immortalized epithelial cells highly tumorigenic, but how this is impacted by other common tumor mutations is not known. In apoptosis-defective cells, inhibition of autophagy by AKT activation or by allelic disruption of beclin1 confers sensitivity to metabolic stress by inhibiting an autophagy-dependent survival pathway. While autophagy acts to buffer metabolic stress, the combined impairment of apoptosis and autophagy promotes necrotic cell death in vitro and in vivo. Thus, inhibiting autophagy under conditions of nutrient limitation can restore cell death to apoptosis-refractory tumors, but this necrosis is associated with inflammation and accelerated tumor growth. Thus, autophagy may function in tumor suppression by mitigating metabolic stress and, in concert with apoptosis, by preventing death by necrosis
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